Multigenerational metabolic profiling in the Michigan PBB registry
نویسندگان
چکیده
منابع مشابه
PBB homologs in sera of Michigan dairy farmers and Michigan chemical workers.
In November, 1976 the Environmental Sciences Laboratory of the Mount Sinai School of Medicine, examined 1029 persons in Michigan for the potential health effects of exposure to PBB. Included in this group were 55 persons from Michigan Chemical Corporation and 237 farming families. Blood serum was analyzed for PBB. FireMaster FF-1 contains several bromobiphenyl components, the major constituent ...
متن کاملDeterminants of polybrominated biphenyl serum decay among women in the Michigan PBB cohort.
Accidental contamination of the food chain in Michigan in 1973 with polybrominated biphenyls (PBBs) led to the establishment of a registry of exposed individuals in 1976. Serum was collected and analyzed for PBB at the time of enrollment and for targeted studies in the following years. We used the archived PBB data to study the elimination of PBB and to identify factors associated with eliminat...
متن کاملNMR-based plasma metabolic profiling in patients with unstable angina
Objective(s): Unstable angina (UA) is a form of the acute coronary syndrome (ACS) that affects more than a third of the population before age 70. Due to the limitations of diagnostic tests, appropriate identification of UA is difficult. In this study, we proceeded to investigate metabolite profiling in UA patients compared with controls to determine potential candidate...
متن کاملCutaneous effects of exposure to polybrominated biphenyls (PBBs): the Michigan PBB incident.
In 1973 an environmental accident occurred in northern Michigan in which 1000-2000 pounds of the toxic fire retardant polybrominated biphenyl (PBB) was added to the livestock food supply of much of northern Michigan. PBB is highly lipophilic. poorly metabolized, and biocumulative. It subsequently entered the human food chain of the entire state of Michigan. Health effects were noted in contamin...
متن کاملRelation of DDE and PBB serum levels in farm residents, consumers, and Michigan Chemical Corporation employees.
Results of serum PBB determinations on 524 Michigan diary farm residents and consumers of products from the farms, 55 chemical workers, and 56 Wisconsin farm residents are reported. Mean and median values were highest for the chemical workers, followed by consumers from and residents of quarantined and nonquarantined farms. Serum DDE was higher among chemical workers, but was similar for all ot...
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ژورنال
عنوان ژورنال: Environmental Research
سال: 2019
ISSN: 0013-9351
DOI: 10.1016/j.envres.2019.02.018